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Pepper spray (also known as OC spray (from "Oleoresin Capsicum"), OC gas, capsicum spray, or oleoresin capsicum) is a lachrymatory agent (a chemical compound that irritates the eyes to cause tears, pain, and even temporary blindness) that is used in riot control, crowd control, and personal self-defense, including defense against dogs and bears. It is a less lethal agent that can be deadly in rare cases. The American Civil Liberties Union documented fourteen fatalities from the use of pepper spray as of 1995.  The active ingredient in pepper spray is capsaicin, which is a chemical derived from the fruit of plants in the Capsicum genus, including chilis. Long-term effects of pepper spray have not been effectively researched.

Pepper spray is an inflammatory.  Pepper spray causes immediate closing of the eyes, difficulty breathing, runny nose, and coughing.  The duration of the effects of pepper spray depend on the strength of the spray but the average full effect lasts around thirty to forty-five minutes, with diminished effects lasting for hours.

Pepper spray typically comes in canisters, which are often small enough to be carried or concealed in a pocket or purse. Pepper spray can also be bought concealed in items such as rings. There are also pepper spray projectiles available, which can be fired from a paintball gun. Having been used for years against demonstrators, it is increasingly being used by police in routine interventions.

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